Why Pesticides are a “Major Cause” of Male Infertility
The authors call pesticides “A MAJOR CAUSE OF MALE INFERTILITY.” This happens for several reasons:
1. Pesticides are responsible for decreasing testosterone concentration either by inhibiting release of follicle stimulating hormone (FSH) or luteinizing hormone (LH) . Pesticides are also responsible for “apoptosis of leydig cells and hence decreasing overall concentration testosterone.” What’s more, pesticides cause increase secretion of hypothalamic corticotrophin-releasing hormone which stimulates the release of adrenocorticotropic hormone (ACTH) and cortisol . High cortisol level inhibit gonadotropin releasing hormone (GnRH). The result? LH and testosterone decrease.
2. Pesticides inhibit acetylcholine esterase, an important chemical that interacts with neurotransmitters in the brain to cause an erection in men.
3. They cause severe oxidative stress.
4. They cause apoptosis and necrosis of cells – a scientific way of saying cells die and shrivel up.
5. Pesticides are endocrine disruptors, which means the hormones which regulate a man’s sexual expression are inhibited or demasculinized.
6. They effect leydig cells which are responsible for creating testosterone and without proper functioning, low sperm count. Glyphosate alone decreases testosterone levels by as much as 37%!
7. Pesticides mess with neurotransmitters that are responsible for creating an erection.
8. They also negatively affect the tunica albuginea, which is the tough fibrous envelope of connective tissue that surrounds the corpora cavernosa of the penis. It consists of approximately 5% elastin, an extensible tissue that is primarily made up of the amino acids glycine, valine, alanine, and proline. The majority of the remaining tissue is collagen, which is made up of lysine, proline, glycine, alanine, and other amino acids